A Comprehensive Exploration

As the fourth leading cause of cancer-related deaths in the United States, pancreatic cancer presents a formidable challenge with a grim prognosis. Moreover, despite strides in understanding the genetic underpinnings of pancreatic cancer, the median survival time remains below 6 months post-diagnosis, with a 5-year survival rate of less than 10%. This article delves into the multifaceted factors contributing to pancreatic cancer, including the role of PFAS chemicals.

In the Hospital Sick Male Patient Sleeps on the Bed. Heart Rate Monitor Equipment is on His Finger.

Environmental Implications of PFOA

PFOA, part of the perfluoroalkyl substances (PFAS) chemical group, played a pivotal role in environmental contamination since the 1940s. Specifically, PFAS consists of over 4,700 persistent chemicals causing widespread ground and surface water pollution. The widespread use of these forever chemicals in products including:

Primarily 3M and Dupont manufactured the chemicals for use in these products. Moreover, the widespread government and civilian use of these products has led to human exposure through various sources, including drinking water, household dust, food products, and firefighting foam exposures.

PFOA Exposure and Human Health

Scientific researchers have linked perfluorooctanoic acid (PFOA) to chemically induced pancreatic cancer. The resistance of PFOA to decomposition in the environment has resulted in detectable levels in 98% of the American population, reaching historical highs in occupationally exposed individuals, like firefighters. Furthermore, epidemiologic studies associate PFOA exposure with adverse health effects, including liver, Leydig, and pancreatic acinar cell tumors, emphasizing its potential carcinogenic impact.

Pancreatic Cancer Progression: A Molecular Landscape

With over 85% of human pancreatic cancers classified as pancreatic ductal adenocarcinoma (PDAC), understanding the molecular landscape is crucial. PDAC progresses through distinct stages, including pancreatic intraepithelial neoplasia (PanIN) and acinar–ductal metaplasia (ADM), with the mutation of the KRAS gene playing a central role.

PFAS Role in Causing Inflammation and Oxidative Stress

Inflammation and oxidative stress emerge as key players in pancreatic cancer progression. Chronic inflammation, particularly in the presence of oncogenic KRAS mutations, significantly increases PDAC incidence. PFOA induces oxidative stress, which is a hallmark of carcinogens. Researchers have demonstrated this through in vitro studies and investigation into PFOA exposure in mouse pancreas.

PFAS Promotion of Pancreatic Cancer

By examining the carcinogenesis stages – initiation, promotion, and progression, researchers revealed PFOA’s potential impact on the promotion stage. This underscores the need for continued research to further understand the environmental impact of PFAS chemicals like PFOA on pancreatic cancer.

OUR team

We prefer doing to talking (except in court), We take the bull by the horns and give you clear and practical advice. Personal, to the point, and in plain language. Any questions? Feel free to call or to drop by.

After reviewing your medical costs, lost wages, and pain and suffering damages, we can help you understand what your case is worth and plan a road map going forward.
After reviewing your medical costs, lost wages, and pain and suffering damages, we can help you understand what your case is worth and plan a road map going forward.

$1.056 billion verdict against Exxon Mobil

If you think you may have a claim and need legal help to hold those parties responsible for damage that they have caused, contact an attorney from our firm.

Stag Liuzza fights industry giants across the country and holds them accountable for their actions. We strive to ensure that communities have access to safe drinking water, clean air, and a healthy environment.

stagliuzza.com is operated and provided by Stag Liuzza, LLC responsible attorneys Michael G. Stag and Ashley M. Liuzza. Stag Liuzza, LLC is officed in New Orleans, LA, and our attorneys are licensed in Louisiana and Mississippi.

Nothing on this site should be taken to establish an attorney-client relationship with us unless and until a contract for representation is signed. The attorneys of Stag Liuzza are licensed in Louisiana and Mississippi and may associate counsel licensed in other jurisdictions as necessary.

Past results do not guarantee any similar result or outcome in your claim. Each claim is different.

This website uses cookies to ensure you get the best experience on our website.